Royal Air Force Typhoon fighter aircraft have joined forces with French warplanes in a combined operation against an underground arms cache in Syrian territory employed by the IS group, as stated by the UK's MoD.
The location, identified by intelligence, was assessed as storing arms and explosives, the release indicated, and was located in mountainous terrain just above the historic site of Palmyra in central Syria.
"Our aircraft used precision-guided Paveway IV munitions to hit a series of approach shafts down to the depot... initial indications are that the target was engaged successfully," the ministry announced.
There was no sign of any civilian impact in the strike late on Saturday and every plane involved made a safe return, the MoD added.
The Typhoon FGR4s were supported by a Voyager refuelling tanker.
Daesh - also known as Daesh - enforced extremist governance over significant areas in both Syria and Iraq prior to its 2019 collapse.
"This strike underscores the UK's leading role, and resolve to work closely with our partners, to stamp out any re-emergence of Daesh and their violent and radical beliefs in the Middle East," the British Defence Secretary the Defence Secretary said.
British military aircraft have performed patrols over Syria to "forestall any attempted comeback" of Islamic State following its military defeat at the climactic battle in Baghuz in 2019, the authorities noted.
"I extend gratitude to every member of the UK armed forces participating in this operation for their professionalism and their valour," Healey said. "Including them were thousands of UK service members deployed over the festive period. This action, to remove militants who threaten our safety, highlights how our armed forces are always on standby, all year round, protecting the UK within its borders and strong abroad."
Last December, the US military conducted what it described as a "major assault" against IS targets in the country, after an assault resulted in the deaths of two US servicemembers and a civilian linguist in the Palmyra area.
The UN estimates IS still boasts between 5,000 and 7,000 combatants in both countries.